![]() All formulations showed distinct Maltese crosses under the polarized light microscope with a positive result for liquid crystals in wide angle X-ray scattering (WAXS) and small angle X-ray scattering (SAXS) methods. In the clinical trial, all formulations were able to reduce transepidermal water loss (TEWL) and increase skin hydration immediately after application. Using the reconstructed human epidermis as a skin model, all formulations did not cause skin irritation. They all showed good stability under normal (room temperature) and accelerated conditions (4 ☌ and 40 ☌) in long-term storage (6 months). All formulations exhibited liquid crystal characteristics with lamellar structures as determined by the polarized light microscopy and small-angle X-ray scattering with supporting data of the nanostructure from wide-angle X-ray scattering and differential scanning calorimetry (DSC). The liquid crystal emulsions were formulated in the form of oil-in-water (o/w) emulsions with Camellia oleifera seed oil serving as the main ingredient in the oil phase (10% w/w). In this study, liquid crystalline emulsions made from camellia seed oil with four different surfactants (Olivem 1000, Polyaquol-2W, Nikkomulese LC, and Lecinol S-10 with Tween 80) were created. Currently, most liquid crystal research focuses on the nanostructure of liquid crystal systems without evaluating the efficacy of liquid crystals clinically. Changing the types and concentrations of surfactants could be another factor that affects liquid crystals. Forming an emulsion into liquid crystals can be affected by a number of factors, including the emulsion composition and temperature. We find the stability of Olivem 1000 is improved with the addition of a water-phase thickener like our Xanthan Gum (Soft or Clear), used at about 0.2%.Ĭonsider the use of a co-emulsifier such as Lotioncrafter GMS (Glyceryl Stearate) at 1 - 2% to further improve stability.įatty alcohols such as Behenyl Alcohol, Cetyl Alcohol or Cetearyl Alcohol can be added to the oil phase for thickening if needed.Liquid crystals are appealing in pharmaceutical and cosmetic fields due to their unique structures that combine the properties of both liquid and solid states. Olivem 1000 has a maximum recommended oil-phase of ~25% (including the emulsifier). Its emulsification mechanism is based on liquid crystal formation and therefore the HLB value is not so critical for this emulsifier. While an HLB value has been provided to us by the manufacturer, Olivem 1000's chemistry does not really work based on the HLB system. Olivem 1000 has a melting temperature of ~70 ☌ and should be added to the heated oil phase. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm. This raw material can be used in the formulation of cosmetics certified according to the ecological and organic standards of EcoCert, COSMOS and Natural ingredient (according to ISO 16128-1:2016).Ĭalifornia Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. ![]() INCI: Cetearyl Olivate (and) Sorbitan Olivate Make-up: mascara, creamy foundations and eye-liners.Face cleansers and deep hydrating emulsions.Olivem 1000 MB is identical to Olivem 1000, but it is manufactured using palm oil that supports the production of certified sustainable palm oil. Safe and clinically tested to be hypoallergenic, it provides creams with an excellent spreadability with no soapy effect. It is an emulsifier and thickener which is compatible with a wide variety of cosmetic and active ingredients over a wide pH range (3 to 12). Olivem 1000 MB is a PEG-free non-ionic oil-in-water emulsifier developed from natural olive chemistry.
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